{"id":27308,"date":"2025-12-11T20:42:58","date_gmt":"2025-12-11T17:42:58","guid":{"rendered":"https:\/\/iletim.istanbul.edu.tr\/?p=27308"},"modified":"2025-12-11T21:22:50","modified_gmt":"2025-12-11T18:22:50","slug":"aziz-sancar-detae-gunlerinin-17ncisi-duzenlendi","status":"publish","type":"post","link":"https:\/\/iletim.istanbul.edu.tr\/index.php\/2025\/12\/11\/aziz-sancar-detae-gunlerinin-17ncisi-duzenlendi\/","title":{"rendered":"Aziz Sancar DETAE G\u00fcnleri\u2019nin 17\u2019ncisi D\u00fczenlendi"},"content":{"rendered":"\n

Muhabir: Zeynep Yolhan \u015eeflek<\/strong><\/p>\n\n\n\n

Foto\u011fraf: S\u00fceda Bayram<\/strong><\/p>\n\n\n\n

Edit\u00f6r: \u00d6zg\u00fcr Recep Kocao\u011flu <\/strong><\/p>\n\n\n\n

\u0130stanbul, (\u0130\u00dc Haber Merkezi) – Aziz Sancar Deneysel T\u0131p Ara\u015ft\u0131rma Enstit\u00fcs\u00fc (DETAE) taraf\u0131ndan Aziz Sancar DETAE G\u00fcnleri\u2019nin 17\u2019ncisi d\u00fczenlendi. <\/strong><\/p>\n\n\n\n

Aziz Sancar Deneysel T\u0131p Ara\u015ft\u0131rma Enstit\u00fcs\u00fc (DETAE) taraf\u0131ndan Aziz Sancar DETAE G\u00fcnleri\u2019nin 17\u2019ncisi 10 Aral\u0131k\u2019ta \u0130stanbul \u00dcniversitesi (\u0130\u00dc) Rekt\u00f6rl\u00fc\u011f\u00fc Doktora Salonu\u2019nda ger\u00e7ekle\u015ftirildi. Program sayg\u0131 duru\u015funda bulunulmas\u0131 ve \u0130stiklal Mar\u015f\u0131\u2019n\u0131n okunmas\u0131yla ba\u015flad\u0131.<\/p>\n\n\n\n

Enstit\u00fcn\u00fcn tarih\u00e7esi ve \u00e7al\u0131\u015fmalar\u0131<\/strong><\/p>\n\n\n\n

Etkinli\u011fin a\u00e7\u0131l\u0131\u015f konu\u015fmas\u0131n\u0131 \u0130\u00dc Aziz Sancar DETAE M\u00fcd\u00fcr\u00fc Prof. Dr. Mustafa \u00d6z\u00e7etin  yapt\u0131.<\/p>\n\n\n\n

\u00d6z\u00e7etin, a\u00e7\u0131l\u0131\u015f konu\u015fmas\u0131nda Aziz Sancar DETAE\u2019nin tarih\u00e7esine de\u011findi. 1945 y\u0131l\u0131nda kurulan enstit\u00fcn\u00fcn 1982 y\u0131l\u0131nda bug\u00fcnk\u00fc yap\u0131s\u0131na kavu\u015ftu\u011fundan bahseden \u00d6z\u00e7etin, 2016 senesinde enstit\u00fcye Nobel \u00f6d\u00fcll\u00fc bilim insan\u0131 Aziz Sancar’\u0131n ad\u0131n\u0131n verildi\u011fini s\u00f6yledi.<\/p>\n\n\n\n

Enstit\u00fcn\u00fcn ara\u015ft\u0131rma, e\u011fitim ve hasta hizmetlerine devam etti\u011fini belirten \u00d6z\u00e7etin; her y\u0131l ortalama 100\u2019\u00fcn \u00fczerinde uluslararas\u0131 yay\u0131n yapt\u0131klar\u0131n\u0131 belirtti. Enstit\u00fc b\u00fcnyesinde projeler ve patentler geli\u015ftirdiklerini aktaran \u00d6z\u00e7etin, 5 anabilim dal\u0131nda y\u00fcr\u00fct\u00fclen toplam 13 y\u00fcksek lisans ve doktora program\u0131yla gen\u00e7 bilim insanlar\u0131na ev sahipli\u011fi yaparak onlar\u0131 yeti\u015ftirdiklerini ifade etti.<\/p>\n\n\n\n

Enstit\u00fcn\u00fcn, Sa\u011fl\u0131k Bakanl\u0131\u011f\u0131 onayl\u0131 t\u0131bbi mikrobiyoloji laboratuvar\u0131na sahip oldu\u011funu s\u00f6yleyen \u00d6z\u00e7etin; laboratuvar\u0131n, t\u0131bbi laboratuvarlarda kalite ve yeterlilik gerekliliklerini belirten \u201cIS0 15189\u201d akreditasyon belgesine sahip oldu\u011funu kaydetti.<\/p>\n\n\n

\n
\"\"
\u0130\u00dc Aziz Sancar DETAE Vekil M\u00fcd\u00fcr\u00fc Prof. Dr. Mustafa \u00d6z\u00e7etin<\/figcaption><\/figure><\/div>\n\n\n

\u00c7ocuk sahibi olmak ve toplum<\/strong><\/p>\n\n\n\n

Etkinli\u011fin ilk konu\u015fmas\u0131n\u0131 ger\u00e7ekle\u015ftiren \u0130\u00dc \u00d6\u011fretim \u00dcyesi Do\u00e7. Dr. Oya Topdemir Ko\u00e7yi\u011fit antropolojik olarak \u00e7ocuk sahibi olmaya ve akrabal\u0131k ba\u011flar\u0131na de\u011findi. Ko\u00e7yi\u011fit, \u00e7ocuk sahibi olmayan \u00e7iftlerin toplumdan ald\u0131klar\u0131 kar\u015f\u0131l\u0131klardan bahsedip \u00f6zellikle kad\u0131nlar\u0131n bu sebeple ya\u015fad\u0131klar\u0131 zorluklar\u0131 anlatt\u0131. Ko\u00e7yi\u011fit, \u00e7ocuk olmamas\u0131 durumunda erkek infertilitesi (k\u0131s\u0131rl\u0131k) d\u00fc\u015f\u00fcn\u00fclmeden \u00e7o\u011fu zaman kad\u0131n\u0131n su\u00e7land\u0131\u011f\u0131n\u0131 ve \u00e7iftlerin \u00e7evresinde bu durumun ataya kar\u015f\u0131 gelmek, g\u00fcnah i\u015flemek gibi do\u011fa\u00fcst\u00fc sebeplere dayand\u0131r\u0131labildi\u011fini s\u00f6yledi.<\/p>\n\n\n\n

T\u00fcp bebek tedavisinin e\u015fler aras\u0131nda birlikte m\u00fccadeleyi peki\u015ftirdi\u011fini, dayan\u0131\u015fma ve payla\u015fma s\u00fcrecini artt\u0131rd\u0131\u011f\u0131n\u0131 anlatan Ko\u00e7yi\u011fit; \u00f6zellikle g\u00f6r\u00fcc\u00fc usul\u00fc evlenmi\u015f \u00e7iftlerin birbirlerini daha iyi tan\u0131mas\u0131n\u0131 sa\u011flad\u0131\u011f\u0131n\u0131 belirtti. Ko\u00e7yi\u011fit, konu\u015fmas\u0131n\u0131 sonland\u0131r\u0131rken infertilite tedavisi s\u0131ras\u0131nda psikolojik deste\u011fin \u00f6nemini vurgulad\u0131.<\/p>\n\n\n

\n
\"\"
Do\u00e7. Dr. Oya Topdemir Ko\u00e7yi\u011fit<\/figcaption><\/figure><\/div>\n\n\n

Kal\u0131tsal kalp rahats\u0131zl\u0131\u011f\u0131 ameliyat\u0131nda geneti\u011fin \u00f6nemi<\/strong><\/p>\n\n\n\n

Ba\u015fak\u015fehir \u00c7am-Sakura \u015eehir Hastanesi\u2019nde g\u00f6rev yapan Prof. Dr. Ali Can Hatemi; kal\u0131t\u0131msal kalp rahats\u0131zl\u0131\u011f\u0131 olan bireylerin ameliyatlar\u0131 planlan\u0131rken, hastalar\u0131n genetik olarak nelere yatk\u0131n oldu\u011funun bilinmesi konusunun \u00f6nemine de\u011findi.<\/p>\n\n\n\n

Kal\u0131tsal kalp rahats\u0131zl\u0131klar\u0131nda, ameliyat\u0131n planlanmas\u0131 ve kullan\u0131lacak ila\u00e7lar\u0131n belirlenmesi s\u00fcrecini kapsayan ki\u015fiselle\u015fmi\u015f protokol\u00fcn \u00f6nemine de\u011finen Hatemi; bu protokol\u00fcn belirlenmesi i\u00e7in hastalar\u0131n genetik taramalar\u0131n\u0131n yap\u0131lmas\u0131 gerekti\u011fini ifade etti. Hatemi, bu uygulaman\u0131n her hastanede yap\u0131lmad\u0131\u011f\u0131n\u0131 ekledi.<\/p>\n\n\n

\n
\"\"
Prof. Dr. Ali Can Hatemi<\/figcaption><\/figure><\/div>\n\n\n

Do\u011fu\u015ftan ba\u011f\u0131\u015f\u0131kl\u0131k kusurlar\u0131<\/strong><\/p>\n\n\n\n

\u0130\u00dc-Cerrahpa\u015fa\u2019da g\u00f6rev yapan Do\u00e7. Dr. Ay\u00e7a K\u0131yk\u0131m, yapt\u0131\u011f\u0131 konu\u015fmada; nadir g\u00f6r\u00fcld\u00fc\u011f\u00fc d\u00fc\u015f\u00fcn\u00fclse de, do\u011fu\u015ftan ba\u011f\u0131\u015f\u0131kl\u0131k kusurlar\u0131n\u0131n her 2 bin ki\u015fiden birinde g\u00f6r\u00fcld\u00fc\u011f\u00fcn\u00fc s\u00f6yledi. Ba\u011f\u0131\u015f\u0131kl\u0131k sistemin sadece az \u00e7al\u0131\u015fmas\u0131 de\u011fil anormal ya da do\u011fru \u00e7al\u0131\u015fmamas\u0131 durumunda da hastal\u0131klara sebep oldu\u011funu vurgulayan K\u0131yk\u0131m, konu\u015fmas\u0131na do\u011fu\u015ftan ba\u011f\u0131\u015f\u0131kl\u0131k kusurlar\u0131 hakk\u0131nda bilgi vererek devam etti.<\/p>\n\n\n\n

S\u0131k enfeksiyon ge\u00e7irmek, ba\u011f\u0131\u015f\u0131kl\u0131k sisteminin kendi h\u00fccrelerine sald\u0131rmas\u0131na sebep olan otoimmun hastal\u0131klar, birden fazla organ\u0131n etkilendi\u011fi hastal\u0131klar, alerjik hastal\u0131klar, s\u0131k s\u0131k g\u00f6r\u00fclen \u00fclser vb. rahats\u0131zl\u0131klar, hatta \u00f6zellikle kan-lenf sistemini etkileyen kanser t\u00fcrleri ba\u015fta olmak \u00fczere kanserin bile ard\u0131nda ba\u011f\u0131\u015f\u0131kl\u0131k kusurlar\u0131 olabilece\u011fine de\u011finen K\u0131yk\u0131m, molek\u00fcler tan\u0131n\u0131n tedavinin belirlenmesinde \u00f6nemli oldu\u011funu belirtti.<\/p>\n\n\n\n

Klinik bilimlerle temel bilimlerin koordineli \u00e7al\u0131\u015fmas\u0131n\u0131n \u00f6nemli oldu\u011funu anlatan K\u0131yk\u0131m, aile \u00f6yk\u00fcs\u00fcn\u00fcn \u00f6nemli oldu\u011funu ve tan\u0131 olmazsa ailenin genetik olarak taran\u0131p sonuca g\u00f6re genetik dan\u0131\u015fmanl\u0131k alamad\u0131klar\u0131n\u0131 ifade etti.<\/p>\n\n\n

\n
\"\"
Do\u00e7. Dr. Ay\u00e7a K\u0131yk\u0131m<\/figcaption><\/figure><\/div>\n\n\n

Genetik kaynakl\u0131 n\u00f6rolojik hastal\u0131klar<\/strong><\/p>\n\n\n\n

\u0130\u00dc \u00d6\u011fretim \u00dcyesi Prof. Dr. P\u0131nar Topalo\u011flu, sebepleri aras\u0131nda kal\u0131t\u0131m\u0131 da bar\u0131nd\u0131ran; epilepsi, kaslarda zay\u0131flama ve k\u00fc\u00e7\u00fclmeye sebep olan spinal muskuler atrofi (SMA), sinirleri \u00e7evreleyen koruyucu zar\u0131n bozulmas\u0131na neden olan l\u00f6kodistrofiler ve adrenol\u00f6kodistrofi gibi genetik kaynakl\u0131 n\u00f6rolojik hastal\u0131klardan bahsetti. Topalo\u011flu ayn\u0131 zamanda bu hastal\u0131klarla ilgili hem bilinen tedavileri hem de tedavilerdeki yeni geli\u015fmeleri anlatt\u0131. Topalo\u011flu, Amerika Birle\u015fik Devletleri G\u0131da ve \u0130la\u00e7 Dairesi FDA\u2019n\u0131n gen terapisi i\u00e7in 2 ya\u015f olan ya\u015f s\u0131n\u0131r\u0131n\u0131 geni\u015fletti\u011fini s\u00f6yledi. Genetik kaynakl\u0131 n\u00f6rolojik hastal\u0131klar\u0131n tedavilerini anlatan Topalo\u011flu, \u201cBaz\u0131 genetik mutasyonlar iyi seyirli olabilir ve iyile\u015febilir\u201d dedi.<\/p>\n\n\n

\n
\"\"
Prof. Dr. P\u0131nar Topalo\u011flu<\/figcaption><\/figure><\/div>\n\n\n

\u00c7evre ve geneti\u011fin ruh sa\u011fl\u0131\u011f\u0131na etkisi<\/strong><\/p>\n\n\n\n

Konu\u015fmas\u0131na \u201cSizce g\u00fcn\u00fcm\u00fcz insanlar\u0131 30 y\u0131l \u00f6ncesine g\u00f6re psikolojik a\u00e7\u0131dan daha mutlu, daha iyi, daha sa\u011fl\u0131kl\u0131 m\u0131?\u201d sorusuyla ba\u015flayan \u0130\u00dc \u00d6\u011fretim \u00dcyesi Prof. Dr. Murat Co\u015fkun, g\u00fcn\u00fcm\u00fczde yakla\u015f\u0131k 3 ki\u015fiden birinin klinik m\u00fcdahale gerektirecek d\u00fczeyde mental-psikolojik rahats\u0131zl\u0131\u011fa sahip oldu\u011funu s\u00f6yledi.<\/p>\n\n\n\n

\u00c7ocuk ve ergenlerde mental-psikolojik hastal\u0131klar\u0131n birinci s\u0131rada oldu\u011funu belirten Co\u015fkun; psikiyatri vakalar\u0131nda geneti\u011fin, pek \u00e7ok hastal\u0131kta oldu\u011fundan daha fazla etkili oldu\u011funu ifade etti. Co\u015fkun, \u00e7evrenin de ruh sa\u011fl\u0131\u011f\u0131nda \u00f6nemli bir etkisi oldu\u011funa de\u011finip de\u011fi\u015fen \u00e7evre ko\u015fullar\u0131n\u0131n, \u00e7evrenin mental sa\u011fl\u0131k ruh sa\u011fl\u0131\u011f\u0131n\u0131 etkiledi\u011fini s\u00f6yledi.Co\u015fkun, Duygusal-davran\u0131\u015fsal sorunlarda \u00e7evre etkisinin daha domine etti\u011fini ifade etti. Bu noktada Co\u015fkun, aileden biri 50\u2019lerinde kalp krizi sebebiyle hayat\u0131n\u0131 kaybetti\u011finde baz\u0131 konulara dikkat edilmesi hususunun psikiyatrik hastal\u0131klarda da ge\u00e7erli oldu\u011funu ve benzer bir mant\u0131\u011f\u0131 oldu\u011funu anlatt\u0131. <\/p>\n\n\n

\n
\"\"
Prof. Dr. Murat Co\u015fkun<\/figcaption><\/figure><\/div>\n\n\n

Mitokondriyal genetik ve hastal\u0131klar<\/strong><\/p>\n\n\n\n

Bezmialem Vak\u0131f \u00dcniversitesi\u2019nde g\u00f6rev yapan Dr. \u00d6\u011fretim \u00dcyesi \u015e\u00fckr\u00fc An\u0131l Do\u011fan, h\u00fccrenin organellerinden mitokondrinin k\u00f6kenini anlatt\u0131. Do\u011fan, konu\u015fmas\u0131na mitokondrinin h\u00fccreye enerji sa\u011flama i\u015flevi ve di\u011fer i\u015flevleriyle devam etti.<\/p>\n\n\n\n

Mitokondrinin kendine \u00f6zg\u00fc bir genomu oldu\u011funu belirten Do\u011fan, mitokondrinin i\u00e7inde birden \u00e7ok mitokondriyal DNA oldu\u011funu s\u00f6yledi. Do\u011fan, mitokondrinin i\u00e7inde normal \u00e7al\u0131\u015fan DNA\u2019lar ve mutant yani de\u011fi\u015fime u\u011fram\u0131\u015f DNA\u2019lar\u0131n bir arada bulunmas\u0131 ve bu iki DNA oranlar\u0131n\u0131n belirli bir e\u015fi\u011fi ge\u00e7mesi halinde hastal\u0131klar\u0131n \u015fekillenece\u011fini belirtti.<\/p>\n\n\n\n

Do\u011fan, mitokondriyal hastal\u0131klar\u0131n beyin, kalp, b\u00f6brek gibi farkl\u0131 organlar\u0131 etkileyebildi\u011fini ifade etti.<\/p>\n\n\n\n

Mitokondriyal hastal\u0131klarda, ayn\u0131 tedavi uygulamas\u0131n\u0131n her zaman ayn\u0131 sonucu vermedi\u011fini anlatan Do\u011fan, ketojenik diyetin baz\u0131 hastalara iyi geldi\u011fini ama baz\u0131 hastalara iyi gelmedi\u011fini s\u00f6yledi.<\/p>\n\n\n

\n
\"\"
Dr. \u00d6\u011fretim \u00dcyesi \u015e\u00fckr\u00fc An\u0131l Do\u011fan<\/figcaption><\/figure><\/div>\n\n\n

Gen\u00e7 ara\u015ft\u0131rmac\u0131lar\u0131n \u00e7al\u0131\u015fmalar\u0131<\/strong><\/p>\n\n\n\n

Etkinli\u011fin son k\u0131sm\u0131 gen\u00e7 ara\u015ft\u0131rmac\u0131lara ayr\u0131ld\u0131. Bu kapsamda \u0130\u00dc\u2019den B\u00fc\u015fra Kasap ve Burcu Keskin konu\u015fmalar\u0131n\u0131 ger\u00e7ekle\u015ftirdi.<\/p>\n\n\n\n

Kasap, beyinde kortikal geli\u015fimsel malformasyonu olan hastalardaki genetik tan\u0131 parametreleriyle ilgili reanaliz \u00e7al\u0131\u015fmas\u0131ndan bahsetti. Bu tan\u0131larla hastalar\u0131n ve ailelerin kafalar\u0131ndaki baz\u0131 sorular\u0131n\u0131n cevab\u0131n\u0131 bulduklar\u0131n\u0131 aktaran Kasap, do\u011fru tedaviye ula\u015fabildiklerini s\u00f6yledi.<\/p>\n\n\n\n

Keskin, inflamatuvar ba\u011f\u0131rsak hastal\u0131klar\u0131 Crohn ve \u00fclseratif kolitten bahsetti; RNF186 gen varyant\u0131n\u0131n ve ba\u011f\u0131rsak ge\u00e7irgenli\u011fini art\u0131ran zonulin protein seviyesinin inflamatuar ba\u011f\u0131rsak hastal\u0131\u011f\u0131yla ili\u015fkisini anlatt\u0131.<\/p>\n\n\n\n

\n
\"\"
B\u00fc\u015fra Kasap<\/figcaption><\/figure>\n\n\n\n
\"\"
Burcu Keskin<\/figcaption><\/figure>\n<\/figure>\n\n\n\n

Program sertifika takdimleri ve foto\u011fraf \u00e7ekimiyle sonland\u0131.
<\/p>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

Muhabir: Zeynep Yolhan \u015eeflek Foto\u011fraf: S\u00fceda Bayram Edit\u00f6r: \u00d6zg\u00fcr Recep Kocao\u011flu  \u0130stanbul, (\u0130\u00dc Haber Merkezi) – Aziz Sancar Deneysel T\u0131p Ara\u015ft\u0131rma Enstit\u00fcs\u00fc (DETAE) taraf\u0131ndan Aziz Sancar DETAE G\u00fcnleri\u2019nin 17\u2019ncisi d\u00fczenlendi.  Aziz Sancar Deneysel T\u0131p Ara\u015ft\u0131rma Enstit\u00fcs\u00fc (DETAE) taraf\u0131ndan Aziz Sancar DETAE G\u00fcnleri\u2019nin 17\u2019ncisi 10 Aral\u0131k\u2019ta \u0130stanbul \u00dcniversitesi (\u0130\u00dc) Rekt\u00f6rl\u00fc\u011f\u00fc Doktora Salonu\u2019nda ger\u00e7ekle\u015ftirildi. Program sayg\u0131 duru\u015funda […]<\/p>\n","protected":false},"author":14,"featured_media":27309,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jnews-multi-image_gallery":[],"jnews_single_post":{"format":"standard"},"jnews_primary_category":[],"jnews_social_meta":[],"jnews_override_counter":[],"footnotes":""},"categories":[24,25,1,159,28,34,2085,2348,32,35],"tags":[3739,1391,43,3218,3738,3570],"class_list":["post-27308","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim","category-egitim","category-genel","category-sag-manset","category-istanbul","category-universite","category-manset-haber","category-manset-yani","category-saglik","category-yasam","tag-aziz-sancar","tag-aziz-sancar-deneysel-tip-arastirma-enstitusu","tag-istanbul-universitesi","tag-ozgur-recep-kocaoglu","tag-sueda-bayram","tag-zeynep-yolhan-seflek"],"_links":{"self":[{"href":"https:\/\/iletim.istanbul.edu.tr\/index.php\/wp-json\/wp\/v2\/posts\/27308","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/iletim.istanbul.edu.tr\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/iletim.istanbul.edu.tr\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/iletim.istanbul.edu.tr\/index.php\/wp-json\/wp\/v2\/users\/14"}],"replies":[{"embeddable":true,"href":"https:\/\/iletim.istanbul.edu.tr\/index.php\/wp-json\/wp\/v2\/comments?post=27308"}],"version-history":[{"count":3,"href":"https:\/\/iletim.istanbul.edu.tr\/index.php\/wp-json\/wp\/v2\/posts\/27308\/revisions"}],"predecessor-version":[{"id":27327,"href":"https:\/\/iletim.istanbul.edu.tr\/index.php\/wp-json\/wp\/v2\/posts\/27308\/revisions\/27327"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/iletim.istanbul.edu.tr\/index.php\/wp-json\/wp\/v2\/media\/27309"}],"wp:attachment":[{"href":"https:\/\/iletim.istanbul.edu.tr\/index.php\/wp-json\/wp\/v2\/media?parent=27308"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/iletim.istanbul.edu.tr\/index.php\/wp-json\/wp\/v2\/categories?post=27308"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/iletim.istanbul.edu.tr\/index.php\/wp-json\/wp\/v2\/tags?post=27308"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}